1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		W	S	K	E	G	H	V	M	T	C	R	I	A	Q	G	L	L	N	D	E	A	A	H	A	V	K	M	L	L	P	E	Y	V	N	G	D	L	S	A	L	C	V	W	P	D	Q	V	R	H	W	Y	K	Y	K	W	T	S	P	L	H
Secondary structure
SS confidence
Disorder		?	?	?																																																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	I	D	T	P	D	K	A	C	N	F	D	Y	E	R	D	C	H	D	Q	H	G	V	K	D	M	C	V	A	G	A	I	Q	N	F	T	T	Q	L	S	H	Y	R	E	G	T	S	D	R	R	Y	N	M	T	E	A	L	L	F	L
Secondary structure
SS confidence
Disorder																					?	?	?	?	?																	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	H	F	M	G	D	I	H	Q	P	M	H	V	G	F	T	S	D	A	G	G	N	S	I	D	L	R	W	F	R	H	K	S	N	L	H	H	V	W	D	R	E	I	I	L	T	A	A	K	D	Y	Y	A	K	D	I	N	L	L	E
Secondary structure
SS confidence
Disorder																																																		?				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	D	I	E	G	N	F	T	D	G	I	W	S	D	D	L	A	S	W	R	E	C	G	N	V	F	S	C	V	N	K	F	A	T	E	S	I	N	I	A	C	K	W	G	Y	K	G	V	E	A	G	E	T	L	S	D	D	Y	F	N
Secondary structure
SS confidence
Disorder										?	?	?																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.
Sequence		S	R	L	P	I	V	M	K	R	V	A	Q	G	G	I	R	L	A	M	L	L	N	N	V	F	G	A	S	Q	Q	E	D	S	V	V	A	T
Secondary structure
SS confidence
Disorder																													?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 54%) Beta strand ( 2%)

Rank Aligned region

PDB 3sng chain A Region: 1 - 267 Aligned: 267 Modelled: 267 Confidence: 100.0% Identity: 100% PDB header:hydrolase Chain: A: PDB Molecule:nuclease; PDBTitle: x-ray structure of fully glycosylated bifunctional nuclease tbn1 from2 solanum lycopersicum (tomato) PDB Entry: PDBe RCSB PDBj Phyre2 PDB 3w52 chain A Region: 1 - 266 Aligned: 256 Modelled: 266 Confidence: 100.0% Identity: 54% PDB header:hydrolase Chain: A: PDB Molecule:endonuclease 2; PDBTitle: zinc-dependent bifunctional nuclease PDB Entry: PDBe RCSB PDBj Phyre2 PDB 1ak0 chain A Region: 1 - 265 Aligned: 255 Modelled: 265 Confidence: 100.0% Identity: 29% Fold: Phospholipase C/P1 nuclease Superfamily: Phospholipase C/P1 nuclease Family: P1 nuclease Phyre2 PDB 5fbf chain A Region: 1 - 268 Aligned: 257 Modelled: 268 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:nuclease s1; PDBTitle: s1 nuclease from aspergillus oryzae in complex with two molecules of2 2'-deoxycytidine-5'-monophosphate PDB Entry: PDBe RCSB PDBj Phyre2 PDB 1ah7 chain A Region: 1 - 271 Aligned: 233 Modelled: 248 Confidence: 100.0% Identity: 15% Fold: Phospholipase C/P1 nuclease Superfamily: Phospholipase C/P1 nuclease Family: Phospholipase C Phyre2 PDB 1kho chain A domain 1 Region: 2 - 265 Aligned: 227 Modelled: 250 Confidence: 98.6% Identity: 17% Fold: Phospholipase C/P1 nuclease Superfamily: Phospholipase C/P1 nuclease Family: Phospholipase C Phyre2 PDB 1olp chain A domain 1 Region: 2 - 274 Aligned: 235 Modelled: 248 Confidence: 98.4% Identity: 17% Fold: Phospholipase C/P1 nuclease Superfamily: Phospholipase C/P1 nuclease Family: Phospholipase C Phyre2 PDB 1olp chain B Region: 2 - 255 Aligned: 221 Modelled: 241 Confidence: 97.4% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:alpha-toxin; PDBTitle: alpha toxin from clostridium absonum PDB Entry: PDBe RCSB PDBj Phyre2 PDB 1gyg chain A Region: 2 - 134 Aligned: 125 Modelled: 125 Confidence: 97.3% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:phospholipase c; PDBTitle: r32 closed form of alpha-toxin from clostridium perfringens strain2 cer89l43 PDB Entry: PDBe RCSB PDBj Phyre2 PDB 1ca1 chain A domain 1 Region: 2 - 265 Aligned: 222 Modelled: 252 Confidence: 96.7% Identity: 17% Fold: Phospholipase C/P1 nuclease Superfamily: Phospholipase C/P1 nuclease Family: Phospholipase C Phyre2 PDB 4xpm chain A Region: 258 - 277 Aligned: 20 Modelled: 20 Confidence: 27.4% Identity: 30% PDB header:protein binding Chain: A: PDB Molecule:protein meh1; PDBTitle: crystal structure of ego-tc PDB Entry: PDBe RCSB PDBj Phyre2 PDB 3d0w chain D Region: 239 - 272 Aligned: 34 Modelled: 34 Confidence: 17.5% Identity: 12% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:yflh protein; PDBTitle: crystal structure of yflh protein from bacillus subtilis. northeast2 structural genomics consortium target sr326 PDB Entry: PDBe RCSB PDBj Phyre2 PDB 2gq1 chain A Region: 90 - 131 Aligned: 37 Modelled: 42 Confidence: 14.9% Identity: 8% PDB header:hydrolase Chain: A: PDB Molecule:fructose-1,6-bisphosphatase; PDBTitle: crystal structure of recombinant type i fructose-1,6-bisphosphatase2 from escherichia coli complexed with sulfate ions PDB Entry: PDBe RCSB PDBj Phyre2 PDB 3waj chain A Region: 1 - 45 Aligned: 45 Modelled: 45 Confidence: 14.7% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:transmembrane oligosaccharyl transferase; PDBTitle: crystal structure of the archaeoglobus fulgidus2 oligosaccharyltransferase (o29867_arcfu) complex with zn and sulfate PDB Entry: PDBe RCSB PDBj Phyre2 PDB 7ns5 chain B Region: 90 - 131 Aligned: 38 Modelled: 38 Confidence: 12.8% Identity: 11% PDB header:hydrolase Chain: B: PDB Molecule:fructose-1,6-bisphosphatase; PDBTitle: structure of yeast fbp1 (fructose-1,6-bisphosphatase 1) PDB Entry: PDBe RCSB PDBj Phyre2 PDB 6qpk chain A Region: 57 - 71 Aligned: 14 Modelled: 15 Confidence: 10.9% Identity: 21% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: zt-kp6-1: an effector from zymoseptoria tritici PDB Entry: PDBe RCSB PDBj Phyre2 PDB 2eou chain A Region: 128 - 141 Aligned: 14 Modelled: 14 Confidence: 10.7% Identity: 36% PDB header:transcription Chain: A: PDB Molecule:zinc finger protein 473; PDBTitle: solution structure of the c2h2 type zinc finger (region 370-2 400) of human zinc finger protein 473 PDB Entry: PDBe RCSB PDBj Phyre2 PDB 2rhs chain B Region: 119 - 155 Aligned: 34 Modelled: 37 Confidence: 9.4% Identity: 21% PDB header:ligase Chain: B: PDB Molecule:phenylalanyl-trna synthetase beta chain; PDBTitle: phers from staphylococcus haemolyticus- rational protein engineering2 and inhibitor studies PDB Entry: PDBe RCSB PDBj Phyre2 PDB 5fug chain I Region: 253 - 263 Aligned: 11 Modelled: 11 Confidence: 9.2% Identity: 45% PDB header:dna binding protein Chain: I: PDB Molecule:vacuolar protein sorting-associated protein 72 homolog; PDBTitle: crystal structure of a human yl1-h2a.z-h2b complex PDB Entry: PDBe RCSB PDBj Phyre2 PDB 3iko chain C Region: 88 - 124 Aligned: 33 Modelled: 37 Confidence: 8.9% Identity: 9% PDB header:structural protein, protein transport Chain: C: PDB Molecule:nucleoporin nup84; PDBTitle: crystal structure of the heterotrimeric sec13-nup145c-nup842 nucleoporin complex PDB Entry: PDBe RCSB PDBj Phyre2 1 c3sngA_ 2 c3w52A_ 3 d1ak0a_ 4 c5fbfA_ 5 d1ah7a_ 6 d1khoa1 7 d1olpa1 8 c1olpB_ 9 c1gygA_ 10 d1ca1a1 11 c4xpmA_ 12 c3d0wD_ 13 c2gq1A_ 14 c3wajA_ 15 c7ns5B_ 16 c6qpkA_ 17 c2eouA_ 18 c2rhsB_ 19 c5fugI_ 20 c3ikoC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48